His heart 'ached' [=he felt sad and sorry] for the children begging on the streets.
Symptoms of the flu include fever, general 'aches and pains', and sore throat.
She looked through the old pictures with a dull 'ache' in her heart.
(..) Truth is, I don't want to know. Some things are best left unsaid. I like to think it was something so beautiful... ...it can't be expressed in words... ...and makes your heart ache because of it. I tell you, those voices soared... ...higher and farther than anybody in a gray place dares to dream. (..)1994 The Shawshank Redemption