He worked to the point of complete/total 'exhaustion'.
the 'exhaustion' of our natural resources
She collapsed in 'exhaustion'.
(..) So I ran to the end of the road, and when I got there I thought maybe I'd run to the end of town. President Carter, suffering from heat exhaustion... And when I got there, I thought maybe I'd just run across Greenbow County. Now, thinking since I'd run this far, maybe I'd just run across (..)1994 Forrest Gump