When the crowd responded to the show so positively, we realized we were 'onto something'. [=we had done/discovered something important, special, etc.]
Scientists believe they are 'onto' something big. [=scientists believe they are close to making an important discovery]
Don't try to shift the blame 'onto' me. [=don't try to blame me instead of the person who should be blamed]
(..) Your guilt has been determined, this is merely a sentencing hearing. Now, what will it be? Death... or... exile? Crane, if you think we're going out onto that ice willingly... you have another thing coming. Death, then. - Looks that way. - Very well. Death... (..)2012 The Dark Knight Rises
(..) That was you in front of the stock exchange, wasn't it? - When? - When? When half the city's cops were tryin' to pull onto Castle Street and your truck was shuttin' them out. - Oh, yeah. You're the cop. - Detective now. And, uh, as a detective, we're not allowed to believe in coincidence. (..)2012 The Dark Knight Rises