They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) I wanted to speak privately. I know there's been trouble with the group, and I apologize that our efforts have caused a rift between y'all. That's a painful thing, I know, and I'm truly sorry it's happened. Yeah, painful. LBJ is not moving, John. I thought he would, but our efforts are not working, (..)2014 Selma