I can tell that something is 'weighing on his mind'. [=that he's worried about something]
She was watching him closely as he spoke, 'weighing him up'. [='sizing him up']
The bad news is really 'weighing on' me.
(..) into that backpack. Now try to walk. It's kind of hard, isn't it? This is what we do to ourselves on a daily basis. We weigh ourselves down until we can't even move. And make no mistake, moving is living. Now, I'm gonna set that backpack on fire. What do you want to take out of it? (..)2009 Up in the Air
(..) -The what? -Do you want the cancer? The cancer? The can, sir? No. I'm fine, thank you. How much does your life weigh? Imagine for a second that you're carrying a backpack. I want you to feel the straps on your shoulders. Feel them? (..)2009 Up in the Air