The weather 'affected' our plans. = The weather had an 'effect' on our plans. [=the weather caused us to change our plans]
This medication may 'affect' your ability to drive a car. [=this medicine may make it dangerous for you to drive a car]
Paralysis 'affected' his limbs. = His limbs were 'affected' by/with paralysis. [=his limbs were paralyzed]
(..) What's most difficult is trying to decide ... ...what to tell you and what not to. Should I tell you about your father? Will it affect your decision to send him back in time to protect me ... ...knowing that he is your father? And he'll be younger than you. Only a teenager when you meet him. (..)2009 Terminator Salvation