The weather 'affected' our plans. = The weather had an 'effect' on our plans. [=the weather caused us to change our plans]
Paralysis 'affected' his limbs. = His limbs were 'affected' by/with paralysis. [=his limbs were paralyzed]
The entire town was 'affected' by their deaths. [=everyone in the town felt sad about their deaths]
(..) - Say you never feel like a father. - Uh-huh. Say your son never feels connected to you as one. Say all of his relationships are affected by this. Do you have a point? You know, you'd think I would. What's up with the simian? It's just a fur ball. Okay, whose turn is it? (..)1995 TvShow: Friends Title: The One with Two Parts: Part 2 Season: 1 Episode 17