She finally achieved/realized/fulfilled her 'life's ambition' [=the thing she most wanted to do in her life] when she started her own business.
He has 'ambitions' for an acting career. = He has 'ambitions' to become an actor. = His 'ambition' is to be/become an actor.
With her talent and fierce 'ambition' [=her very strong desire to succeed], she became a very successful actress.
(..) Yes. Except that they're welded in. What we need is a controlled expolsion. We need a container to direct the blast my clay pipe should service that ambition I rather wish you hadn't done that, Irene. On the twelfth chime, I will summon the dark powers. All of those who are with (..)2009 Sherlock Holmes