The surgery required a 'general anesthetic'. [=a drug that makes a person unconscious and unable to feel pain]
a 'local anesthetic' [=a drug that makes a part of the body unable to feel pain]
The doctor gave him the stitches without an 'anesthetic'.
(..) As per usual, "Nanny". Oh, his killed the dog... again. What have you done to, Gladston now? I was simply testing a new anesthetic. He doesn't mind. Holmes as your doctor... He'll be good in no time. As your friend... (..)2009 Sherlock Holmes