Researchers say they have made/achieved a major 'breakthrough' in cancer treatment.
The police have announced a 'breakthrough' in the murder case.
This job could be the 'breakthrough' she's been waiting for.
(..) how to do one. Hey, w-wouldn't it be funny if after all your years of hard work, I'm the one who makes a scientific breakthrough? He doesn't think that's funny. (static crackling) (gasps) (sighs) (..)2016 TvShow: The Big Bang Theory Title: The Solder Excursion Diversion Season: 9 Episode 19