Researchers say they have made/achieved a major 'breakthrough' in cancer treatment.
The police have announced a 'breakthrough' in the murder case.
This job could be the 'breakthrough' she's been waiting for.
(..) Ella's a nice name. What? The next one? / Okay. I don't want her watching our baby. Ross, I am trying to help her become a better person. This is a huge breakthrough for her She just offered to do something for another human being Honey, I, I don't know Ross, I'm telling you. She's giving up (..)2003 TvShow: Friends Title: The One Where Rachel's Sister Babysits Season: 10 Episode 5