Researchers say they have made/achieved a major 'breakthrough' in cancer treatment.
The police have announced a 'breakthrough' in the murder case.
This job could be the 'breakthrough' she's been waiting for.
(..) Come on, kids, let's go. The berg is moving. But, dad. . . No "but". You can play later. Okay. Come on, guys. Sally, where's Eddie? He said something about being on a verge of a revolutionary breakthrough. Really? I'm flying! Some breakthrough. Look out! A mammoth is on its way. (..)2002 Ice Age