Researchers say they have made/achieved a major 'breakthrough' in cancer treatment.
The police have announced a 'breakthrough' in the murder case.
This job could be the 'breakthrough' she's been waiting for.
(..) You think it's Irma? Yes. Don't you? No! I'm a man! We're men! Well, if it's true, it's the scientific breakthrough of the afternoon. It's not true! Don't worry, I wasn't about to look foolish by jumping to conclusions, (..)2006 TvShow: The IT Crowd Title: Aunt Irma Visits Season: 1 Episode 6