The new drug acts as a clot-'buster'. [=it causes blood clots to break apart]
crime'-busters' [=people who stop crimes, who catch criminals, etc.]
Wait a minute, 'buster'. You're trying to trick me, aren't you?
(..) This town ain't big enough for the two of us. What? Somebody's poisoned the water hole. -It's busted. -Who are you callin' busted, buster? That's right. I'm talking to you, Sid Phillips. We don't like bein' blown up, Sid, or smashed or ripped apart. -"We"? (..)1995 Toy Story