The new drug acts as a clot-'buster'. [=it causes blood clots to break apart]
crime'-busters' [=people who stop crimes, who catch criminals, etc.]
Wait a minute, 'buster'. You're trying to trick me, aren't you?
(..) have never believed me. - Jimmy, could I talk to you now? - You're a pisser. A real pisser. Want to talk now? Okay, let's talk. I've never met a ball buster like you. Who loves you more than I do? - I'd do anything for you. - Except stop busting my balls. - Let's go have coffee. (..)1990 Goodfellas