She struggled with depression for years, but she's more 'centered' now and able to live a full life.
The investigation has 'centered' [='focused'] mainly 'on/upon' the alleged misuse of public funds.
She 'centers' her life 'on/around' her children. = Her life is 'centered on/around' her children.
(..) - Mind if I come with you? - Not at all. Okay, higher. Higher. Yep, higher. Nope, wait! No! To... Okay, now to... Look, that doesn't look centered to me, it just... Excuse me! Hey, Sister. Ain't your time through here? I thought you weren't allowed to put that up. No? (..)2013 TvShow: Orange Is the New Black Title: The Chickening Season: 1 Episode 5