The team is looking to 'defend' its national title. [=to win the national title again]
As a U.S. senator, it is my responsibility to 'defend' [='uphold'] the Constitution.
She successfully 'defended' her championship. [=she won the championship again]
(..) Time to go then. Are you sure you need such huge doses? I'm afraid you won't survive. Some cells inside me will fight and defend their integrity to the very end. In order to attain the last few percent, I've to force it. To crack the cells open to their nucleus. All these knowledge, Lucy... (..)2014 Lucy