The company's managers don't want to 'depart from' an approach that has worked well in the past. [=they do not want to change their approach]
The actors were not allowed to 'depart from' the script. [=they were not allowed to say anything that was not in the script]
The river 'departs' [='turns', 'deviates'] 'from' its original course a few miles downstream.
(..) l'm giving you my ticket. - Here. - Thanks! But l'm-- Oh, tut-tut-tut-tut, l insist. Your health comes fi rst. Come, the coach departs at midnight. Hi diddle dee dee lt's Pleasure lsle forme Where everyday is a holiday Andkids have nothing to do butplay - Pinoke! - Hi diddle dee dee (..)1940 Pinocchio