This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) I love her. I love her... and I can't help her. We must be strong for those we love. We cannot give in to despair. I will speak with the High Sparrow. There must be something he... Let me talk to him (..)2015 TvShow: Game of Thrones Title: The Gift Season: 5 Episode 7