This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) Let me tell you the truth. The break-up with Cecilia has hardened me. I'm becoming hard. With myself, with others. I'd learned never to despair when times are tough. Or to get elated when things are good. Fuck. I'm going to sleep. (..)2016 Me Before You