This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) I don't need a visitor. SETH: You're not ill? No. I'm one of the doctors here. Are you in despair? I lost a patient. You did everything you could? I was holding his heart in my hand when he died. Then he wasn't alone. (..)1998 City of Angels