This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) - Now, about your book, it's very unusual, indeed. I mean, in a way, it's almost like science fiction. We all fear death, and question our place in the universe. The artist's job is not to succumb to despair, but to find an antidote for the emptiness of existence. You have a clear and lively voice. (..)2011 Midnight in Paris