This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) Where doctors and nurses dedicate their lives... to that wonder which is a human being. ...an ever-changing challenge of love and hope, loneliness and despair. General Hospital on ABC. Doctors and nurses with first names and last names, and tragedies of their own. - Oh, I'm so sorry. - Excuse me. (..)2014 Annabelle