This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) -You came from Sunnyside? -But how'd you escape? Well, it wasn't easy. What do you mean ''escape''? Sunnyside is a place of ruin and despair. Ruled by an evil bear who smells of strawberries. Lotso? The guy may seem plush and huggable on the outside, (..)2010 Toy Story 3