This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) (music) lift me up sometimes (music) (music) I will feel better (music) (music) better (music) Michael Jackson: In my darkest hour, In my deepest despair... Will you still care? Will you be there? In my trials... And my tribulations... Through all doubts... (..)1993 Free Willy