This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) I would have you smile again... ...not grieve for those whose time has come. You shall live to see these days renewed... ...and no more despair. What kind of army would linger in such a place? One that is cursed. Long ago, the Men of the Mountains swore an oath... (..)2003 The Lord of the Rings: The Return of the King