This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) Jeff, you know if someone came in here, they wouldn't believe what they'd see. What? You and me with long faces, plunged into despair... because we find out a man didn't kill his wife. We're two of the most frightening ghouls I've ever known. You'd think we could be (..)1954 Rear Window