This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) So easy. So simple. And like shipwrecked men turning to seawater from uncontrollable thirst... many have died trying. I learned here that there can be no true despair without hope. So... as I terrorize Gotham, I will feed its people hope to poison their souls. I will let them believe (..)2012 The Dark Knight Rises
(..) But not of your body. Of your soul. - Where am I? - Home. Where I learned the truth about despair. As will you. There is a reason why this prison is the worst hell on earth. Hope. Every man who has rotted here (..)2012 The Dark Knight Rises