This latest setback has brought/carried/driven her 'to the depths of despair'.
We had begun to 'despair of' ever finding a house we could afford.
The people were 'driven to despair' by the horrors of war.
(..) Kung fu is dead? Fine! You stay in your prison of fear with bars made of hopelessness. And all you get are three square meals a day of shame! With despair for dessert. We'll take on Shen and prove to all those who are hungry for justice and honour that kung fu still lives! Yeah! (..)2011 Kung Fu Panda 2