His phenomenal success carried within it the 'seeds of its own destruction'. [=the thing that made him successful eventually caused him to fail]
His drinking started him 'on the path/road to self-destruction'.
We are trying to save the building from 'destruction'.
(..) but it was this... it was this that allowed them to do it. We fear the Witness, yet my attempt to rewrite history resulted in the destruction of time itself. You don't get to decide it's over just because you've given up hope. We've exhausted hope, James. No, Cole, we have to stop this. Lasky... (..)2016 TvShow: 12 Monkeys Title: Lullaby Season: 2 Episode 8
(..) one that ravaged time itself... a plague whose origins can be traced back to one single moment. No cult. No investigation needed. The true catalyst for the destruction of mankind is standing before your eyes. I sent Cassie back to Spearhead in with the explicit instruction to end my life (..)2016 TvShow: 12 Monkeys Title: Lullaby Season: 2 Episode 8