The mayor is 'gambling' that the new policies will help rather than hurt the city.
The company is 'gambling' [='betting, risking'] everything 'on' this strategy.
people who lost money 'gambling' in the stock market
(..) he plans to travel to the launch site... In order to make contact with us, but it would be a dangerous gamble. Thank you very much. Don't say "bring him home alive," Vincent. You know what? These interviews (..)2015 The Martian