Their plans for opening a restaurant 'came to grief' when they failed to get a loan.
He has been unable to recover from his 'grief' at/over his son's death.
“He's burned the toast.” “'Good grief'! Can't he do anything right?”
(..) Give us a curse. Well, my dad did tell me about one. The lmperius Curse. Oh, yeah, your father would know all about that. Gave the Ministry quite a bit of grief a few years ago. Perhaps this will show you why. Hello. Lovely little beauty. Engorgio. (..)2005 Harry Potter and the Goblet of Fire