Their plans for opening a restaurant 'came to grief' when they failed to get a loan.
He has been unable to recover from his 'grief' at/over his son's death.
“He's burned the toast.” “'Good grief'! Can't he do anything right?”
(..) Dialogue: Marked=..,Default,NTP,!Effect,Go on. On with you. On with you now.\NOh, listen, Harry. Dialogue: Marked=..,Default,NTP,!Effect,lf that dolt of a cousin of yours,\NDudley, gives you any grief... Dialogue: Marked=..,Default,NTP,!Effect,...you could always threaten him... (..)2001 Harry Potter and the Sorcerer's Stone