Looking up at the stars always makes me feel so small and 'insignificant'.
They lost an 'insignificant' amount of money.
These problems are 'not insignificant'.
(..) - Well, he took your gun. Cracked your head. Slammed you across the room. - Half the time you were on your back. - Look, that's how I fight. You've lost, you insignificant speck. You've wasted years of my time, and for what? The total annihilation of Zartha. All because you went mushy. (..)2002 Men in Black II