Her comments were 'irrelevant to' our discussion.
He talked 'irrelevantly' about the weather.
His comment is completely 'irrelevant'.
(..) Has it ever crossed your brilliant mind that I don't want to do this anymore? Whether it has or hasn't is irrelevant. I will not negotiate with you, Severus. You agreed. Nothing more to discuss. Oh, Harry... (..)2009 Harry Potter and the Half-Blood Prince