It's 'lonely at the top'. [=powerful and successful people often have few friends]
He was/felt 'lonely' without his wife and children.
the 'lonely hearts' section of the newspaper
(..) ♪ as a kite by then ♪ ♪ ♪ I miss the earth so much, I miss my wife ♪ ♪ ♪ it's lonely out in space ♪ ♪ on such a timeless flight ♪ ♪ ♪ and I think it's gonna be a long, long time ♪ ♪ till touchdown brings (..)2014 TvShow: Californication Title: Grace Season: 7 Episode 12