I'm sorry to be such a 'nuisance' [=I'm sorry to bother you], but I need your help again.
The sticky clay was a 'nuisance' to work with. [=was difficult to work with]
He 'made a nuisance of himself'. [=he behaved in an annoying way]
(..) What I'm saying is, if you want to go, I won't stop you, but the minute you start to whine or make a nuisance, I don't care where we are, I'm dumping you flat. Don't sugarcoat it like that, Kid. (..)1969 Butch Cassidy and the Sundance Kid