They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) Look, I know you and she had some weird interspecies simpatico going on, but she was a fucking host. This was never gonna end any other way. And this was the least painful way she's ever gone out. You know, I saved your ass. You can't even say "thank you." - Thank you. - Jesus fuck! (..)2016 TvShow: Westworld Title: Trace Decay Season: 1 Episode 8