They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) "Some mistakes, such as Madam Curie's discovery of radium, "turned out to have great scientific potential, "even though she would later die a slow, painful death "from radiation poisoning. Another example, from the field of Ebola research..." We're okay. - Six two inch dowels. - Check. (..)2007 TvShow: The Big Bang Theory Title: The Big Bran Hypothesis Season: 1 Episode 2