They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) the trunk of the victim's car. It's either yours or your mom's. You have an alibi, and she doesn't. My mom wouldn't do that. This is clearly painful for you. I-I misunderstood your relationship with your mother. She was the one who'd do anything to protect you. (..)2014 TvShow: Bones Title: The Master in the Slop Season: 9 Episode 14