They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) (sirens wailing) Whoa! That's one hell of a way to park a bike. HODGINS: Must've been a gnarly landing. Yeah, gnarly and painful. The mountain biker said that this bone lodged itself into his arm. The sub-pubic angle of the pelvis (..)2015 TvShow: Bones Title: The Promise in the Palace Season: 11 Episode 7