They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) some more wine? Well, that-that would be good. Thank you. The truth is, it was painful. How so? Turning him down. Saul recruited me, he trained me. He's pulled so many hatchets (..)2015 TvShow: Homeland Title: A False Glimmer Season: 5 Episode 12