They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) We'll have our coffee, and I'll take you home. No. You do it now. Axe? You better do some painful thinking. Unless you come to terms with why you're doing this... no money's gonna get you out. - Who is it? - What do you mean who is it? (..)1974 The Gambler