They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) -It's an experience. -Certainly is. There's a first time for everything. -Sure enough. Your drinks. I don't mean to be rude... but your hands, is that painful? I was born with some form of disease. -What kind of disease? I was born old. -I'm sorry. -No need to be. Nothing wrong with old age. (..)2008 The Curious Case of Benjamin Button