They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) I love you too. I realize, Miss Prentice, but you still have time. Mind if I look around? But wouldn't you be more comfortable sitting down? I do know how painful this must be for you. Look, it had absolutely nothing to do with the money! Look, I don't even want to talk about it. (..)2014 Annabelle