They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) -Let's let Molly open one. Frankincense, this is Myrrh. Hey, heads up, everybody. It's show time. Whoa! It's time! Oh, Bo. There's got to be a less painful way to get my attention. Merry Christmas, Sheriff. Say, isn't that mistletoe? Maybe Andy will get another dinosaur. Like a leaf eater. (..)1995 Toy Story