They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) Medication side effect. Doctors call these "Ghost pains". I always say that I'm a frozen steak thrown in a hot frying pan. I don't feel anything, but it's still painful. It has to stop. There must be something that will relieve you. Yup. This could relieve me. Well, we're all a little sick (..)2011 The Intouchables