They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) Po, the day you were chosen as Dragon Warrior was the worst day of my life. By far. Nothing else came close. It was the worst, most painful, mind-destroying, horrible moment... - OK. ...I have ever experienced. But once I realised the problem was not you, but within me, (..)2011 Kung Fu Panda 2