They made it 'painfully' obvious/clear that we were not welcome. [=they made it very clear in a way that was rude or upsetting that we were not welcome]
His ankle is swollen and 'painful to the touch'. [=his ankle hurts if he touches it]
After the injury she was 'painfully' aware that her career in tennis would be over.
(..) Just something I say to myself when I think my ass looks fat. So you do understand what I've been going through. I know, changes in the body can be painful. But remember, your body is just the ship. Your soul is the passenger. There's another passage here. - So you been through menopause? (..)2013 TvShow: Orange Is the New Black Title: The Chickening Season: 1 Episode 5