Computer technology has made 'profound' [='major, significant'] changes in our lives.
His paintings have had a 'profound' effect/impact/influence on her own work.
Her books offer 'profound' insights into the true nature of courage.
(..) who have been robbed of their freedom, of their happiness and, in the saddest of cases, of their bodies. So in many ways I have to thank the thief for creating my most profound piece of work to date. A woman robbed. Now I would ask you all to leave your genitals at the door (..)2016 TvShow: Fleabag Title: Episode #1.6 Season: 1 Episode 6